讲座题目：Tissue Biofabrication—A New Paradigm Shift in Regenerative Medicine

主 讲 人：叶开明教授

讲座时间：2018年 12月6日下午2：00-3:00

讲座地点：理学院钱伟长楼201会议室

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讲座内容简介：

Creation of highly organized multicellular constructs, including tissues and organoids, will revolutionize tissue engineering and regenerative medicine. The development of these technologies will enable the production of individualized organs for patient-tailored organ transplantation or individualized tissues for cell-based therapy. These lab-produced high order tissues and organs can serve as disease models for pathophysiological study and drug screening. This lecture will discuss grant challenges in the emerging field of advanced biomanufacturing. The discussions will be more focused on the development of new tissue biofabrication technologies and how these developments will lead to new models of generating tissue organoids, automated and closed systems, systems for a range of needs from cell culture medium formulation to biomaterial formulation, stem cell differentiation and tissue development/assembly, functionality assessment, in- or on-line sensing, product release evaluation, QA/QC, and supply chain. This concept of advanced biomanufacturing shifts the emphasis from massive production of uniform biomedical products to high-volume, small-scale production of customized tissue products that have a short shelf life. These challenges necessitate a radical manufacturing paradigm shift from conventional, centralized, off-the-shelf medicinal products to a new class of cell- and tissue-based products for precision medicine. The ultimate realization of new manufacturing practices for human cell and tissue clinical application demands a decentralized yet standardized model, providing reliable and robust manufacturing at regional facilities. These regional facilities must manufacture, test, store and distribute cell products safely and efficiently to patients as needed. We have developed an innovative tissue assembly technologies for developing islet organoids from human pluripotent stem cells (HPSCs) and technologies needed for printing small diameter blood vessels for transplantation. We showed that islets can be fabricated from hPSCs. The further optimization of the process will enable the biofabrication of human islets. The fabricated islets can be used for diabetes treatment, drug screening/toxicity validation, and pathophysiological study. Along these lines, we have recently successfully developed a new bioink that possess a shear-thinning property ideal for islet 3D bioprinting. We tested the bioink in blood vessel printing and will move to islet printing upon the success of blood vessel printing. In addition, this lecture will discuss grand challenges in workforce training in biomanufacturing.

报告人简介：

叶开明博士是纽约州立大学宾汉姆顿分校生物医学工程学教授、药理学教授，现担任沃森工程学院生物医学工程系系主任，生物制造与再生医学研究中心主任。他是医学和生物工程领域最杰出和最有成就的领军人物之一。他是美国医学与生物工程院 (AIMB) 理事，也是电气电子工程师协会 (IEEE) 资深会员。学术方面，叶开明教授发展了先进生物制造的概念，促进并引领了该领域的重大进展。他主办或共同主办了超过12个科研培训会议，包括两个世界技术评估中心的科研培训计划：干细胞科学与工程全球评估，和先进生物制造技术与发展的全球评估。叶开明教授开发了具有荧光实时动态检测功能的生物打印平台，并应用于类器官组织发育的研究。他在组织生物打印和胰腺类器官发育方面的工作被广泛报道；他在先进生物制造方面的工作被美国工程教育学会的PRISM杂志作为封面故事报道；他在葡萄糖传感器方面的工作被匹兹堡Post-Gazette 杂志报道。叶开明教授的科研一直受到美国国立卫生研究院(NIH)，国家科学基金会(NSF)，美国国家标准局(NIST)，青少年糖尿病研究基金会(JDRF)，ABI以及工业界的资助。他作为主席或者共同主席主办了很多国际会议。他多次在国际会议上做特邀报告。

作为一个管理者，叶开明教授也是成就斐然。他曾对美国政府在科学与技术方面的政策制定做出过重要贡献。他在美国国家科学基金会 (NSF) 任职期间，曾担任生物医学工程部主任，负责基金分发与管理。他也曾服务于多个美国政府部委间协调工作组，包括美国总统科技政策办公室下辖的神经科学跨部委工作组，国家科学与技术委员会，跨部委医学建模与分析小组，以及组织工程与再生医学项目的多部委工作组等。此外，他还参与了NSF的21世纪研究生培养计划、网络时代高等教育新模式发展计划、NIH/NSF联合主办的物理与生命科学交叉项目、和物理工程科学与癌症交叉的项目。叶开明教授在生物工程教育领域很有成就，宾汉姆顿大学的生物医学工程学系在他的领导下取得了巨大发展。